603 papers
This study reveals that the AAA+ ATPase FIGNL1 prevents age-dependent accumulation of RAD51 on non-damaged chromosomes in mammalian oocytes, a process whose failure leads to defective chromosome condensation and meiotic arrest due to the mislocalization of condensin II and topoisomerase II.
This study establishes an optimized protocol for isolating, expanding, and differentiating canine intestinal organoids from the duodenum and colon, demonstrating that 100 nM PGE2 enhances growth and a two-phase differentiation approach yields functional, marker-positive models suitable for future disease research and translational applications despite a limited sample size.
By applying quantitative 3D soft X-ray tomography to intact INS-1E cells, this study reveals that high glucose and Exendin-4 stimulation induce a coupled remodeling of mitochondrial shape, metabolic density, and subcellular location, establishing a structure-density-location relationship across different mitochondrial morphotypes.
The study reveals that the human rhomboid protease RHBDL2 acts as a calcium-activated suppressor of EGFR signaling in keratinocytes by shedding the receptor's ectodomain, thereby limiting cell migration and invasion while promoting proper skin differentiation.
This study identifies SUN2 as a critical nuclear mechanosensor that mediates epigenetic remodeling by coupling extracellular matrix stiffness to chromatin regulation and fibrotic gene expression, thereby driving skin fibrosis and representing a potential therapeutic target.
This study establishes that MORC2 mediates transcriptional silencing through DNA-templated liquid-liquid phase separation, where dynamic condensates driven by specific structural interactions are essential for its repressor function and whose dysregulation underlies human neuropathies.
This study characterizes the diverse regulatory outcomes of introducing over 20 human cancer mutations into the Drosophila Notch Negative Regulatory Region, revealing distinct mechanisms of constitutive activation and synergy with PEST deletions that depend on the specific mutation location and its impact on protein stability and ligand responsiveness.
The paper introduces SteMClass, a novel DNA methylation-based classifier that accurately and harmoniously identifies various iPSC differentiation states across different protocols and array versions, thereby establishing a standardized quality control framework to enhance reproducibility and accelerate clinical translation in regenerative medicine.
This study reveals that early cytokinetic events in zebrafish dorsal forerunner cells instructively drive cytoskeletal reorganization, actin recruitment, and rosette formation, which are essential for the Kupffer vesicle's detachment from the enveloping layer and subsequent lumen morphogenesis.
This study identifies GEM, a metastable 34-nm nano-liquid hub on the plasma membrane that physically integrates growth and immune-evasion signaling through LLPS-like clustering, thereby amplifying survival pathways and promoting tumor growth in vivo.