361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study demonstrates that boldine, an alkaloid from *Peumus boldus*, prevents diabetes-induced skeletal muscle dysfunction, lipid accumulation, and inflammation in mice and human myoblasts by inhibiting large-pore channel activity and subsequently suppressing calcium-dependent inflammasome activation and adipogenic pathways.
This paper introduces an optimized enzymatic digestion and serum-free culture method that enables long-term ex ovo development of *C. elegans* embryos, thereby overcoming eggshell permeability barriers to allow precise pharmacological manipulation and study of developmental processes through adulthood.
Using high-throughput single-cell imaging, this study demonstrates that Topologically Associating Domain (TAD) boundary architecture and gene activity are largely uncoupled, as TAD boundary interactions are infrequent and independent of transcriptional status, while disrupting TAD boundaries does not alter gene expression.
This article reviews the formation and structure of Envelope-Limited Chromatin Sheets (ELCS) in retinoic acid-induced HL-60/S4 granulocytes, highlighting the critical role of increased Lamin B Receptor (LBR) synthesis and cholesterol biosynthesis in creating these flexible nuclear outgrowths, while contrasting these features with the lack of ELCS and reduced LBR in phorbol ester-induced macrophages.
This study identifies the RasGAP C2GAP1 as a critical, F-actin-independent effector that directly couples with the heterotrimeric G protein G2 to mediate concentration-dependent adaptation and maintain sensitivity during chemotaxis in *Dictyostelium discoideum*.
This study elucidates how endothelial cell-derived extracellular vesicles, through the transcription factor ETV1 and specific microRNAs, prime dermal fibroblasts to undergo a transcriptomic and phenotypic shift resembling FGF2-mediated cancer-associated fibroblast activation, thereby defining a key mechanism in cutaneous wound repair.
This study introduces intravital single-molecule microscopy (iSiMM) to directly track cytoskeletal dynamics in live mice, revealing that regulated molecular turnover within pre-existing membrane infolds drives rapid membrane remodeling and cell expansion in response to physiological stimulation.
This study identifies *Plasmodium falciparum* SR12 as a GOLD-domain seven-transmembrane protein that structurally resembles mammalian GOST proteins and functions as a chaperone to promote GPCR trafficking to the plasma membrane in mammalian cells.
This study utilizes mass spectrometry to demonstrate that the extreme anoxia tolerance of *Austrofundulus limnaeus* WS40NE cells is supported by dynamic changes in both histone post-translational modifications and histone isoform abundance during oxygen deprivation and recovery.
This study identifies a novel mechanism where platelets utilize actomyosin-driven swirling motions to actively wind and compact fibrin fibers into dense structures, thereby reducing clot volume and enhancing wound repair.